Potentiation by Caffeine of Potentially Lethal Fast-Neutron Damage in Cultured Human Cells
- 1 November 1980
- journal article
- letter
- Published by JSTOR in Radiation Research
- Vol. 84 (2) , 353-358
- https://doi.org/10.2307/3575305
Abstract
Caffeine potentiated single-dose fast-neutron-induced killing of human T-1 cells when present at 2 mM for 60 h or more after (and 10 h before) irradiation. The survival curves of cells treated with neutrons or X-rays with and without caffeine indicate that only the linear, low-dose portion of survival curves was modified. Potentiation of lethality by caffeine was mainly attributed to its effects on single-hit potentially lethal lesions, possibly certain DNA double-strand breaks.This publication has 2 references indexed in Scilit:
- Caffeine Enhancement of X-Ray Killing in Cultured Human and Rodent CellsRadiation Research, 1978
- Survival-related DNA repair phenomena in cultured rat-kangaroo cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976