Over-All Glucose Utilization in Steroid Diabetic Guinea Pigs

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Abstract
The over-all glucose utilization of guinea pigs was determined during a pre-experimental period, and during the period of marked steroid diabetes produced by administration of cortisone or hydrocortisone. The amount of glucose utilized was calculated from the carbohydrate content of the food consumed, from the gluconeogenesis from protein using a D/N ratio of 3.65, and from the amount of glucose excreted in the urine. It was assumed that all proteins estimated from the urinary non-protein nitrogen are equally utilized for gluconeogenesis in the control and experimental periods. All animals injected with diabetogenic doses of steroids and maintained in a healthy condition compensated the glucose loss fully by increased food intake, and increased gluconeogenesis. The amount of glucose utilized during the diabetic stage was not diminished.