Tetracycline and Demethylchlortetracycline in Man
- 1 August 1962
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 110 (2) , 166-169
- https://doi.org/10.1001/archinte.1962.03620200026006
Abstract
In 1957 McCormick et al.1 published an account of a new family of tetracycline derivatives, the demethyltetracyclines. In 1958 Kunin and Finland2 reported a comparative study of equal doses of tetracycline (TC) and demethylchlortetracycline (DMCT) in man in which they demonstrated quite clearly that DMCT was more active than TC against 3 test organisms (including a group A β-hemolytic streptococcus, a staphylococcus, as well as the customary organism used in tetracycline assays, Bacillus cereus) and produced significantly higher and more sustained anti-microbial levels by weight for each organism following oral ingestion. These studies were confirmed and extended by the reports of Sweeney et al.,3 Hirsch and Finland,4 Garrod and Waterworth,5 and others. The pertinent literature has been reviewed by Finland and Garrod6 and Kunin and Finland.7 The chemotherapeutic advantage of DMCT over TC has been shown to be due to: (1) delayed renalThis publication has 0 references indexed in Scilit: