Determination of the Steady State Tissue Distribution of Midazolam in the Rat
- 1 August 1996
- journal article
- Published by American Geophysical Union (AGU) in Journal of Pharmaceutical Sciences
- Vol. 85 (8) , 887-889
- https://doi.org/10.1021/js960113+
Abstract
The aim of this study was to determine the steady state tissue:blood (Kb), tissue:plasma (Kp), and tissue:plasma water (Ku) partition coefficients of midazolam in all major organs and tissues in the rat, after development of a gas chromatographic assay. The Kp in 12 tissues ranged between 1.3 (in muscle) and 9.0 (in fat). Ku ranged correspondingly between 16 and 115.Keywords
This publication has 14 references indexed in Scilit:
- Pharmacodynamic interaction between midazolam and a low dose of ethanol in vivoLife Sciences, 1995
- Tissue distribution of fentanyl and alfentanil in the rat cannot be described by a blood flow limited modelJournal of Pharmacokinetics and Biopharmaceutics, 1993
- Pharmacokinetic‐pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administrationBritish Journal of Pharmacology, 1991
- Comparative Tissue Concentration Profiles of Fentanyl and Alfentanil in Humans Predicted from Tissue/Blood Partition Data Obtained in RatsAnesthesiology, 1990
- High-performance liquid chromatographic method for determining thiopental concentrations in twelve rat tissues: Application to physiologic modeling of disposition of barbiturateJournal of Chromatography B: Biomedical Sciences and Applications, 1989
- Simultaneous determination of fentanyl and alfentanil in rat tissues by capillary column gas chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1988
- Measurement of midazolam and α-hydroxymidazolam by gas chromatography with electron-capture detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1986
- MidazolamAnesthesiology, 1985
- Effect of Age, Gender, and Obesity on Midazolam KineticsAnesthesiology, 1984
- Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic modelJournal of Pharmacokinetics and Biopharmaceutics, 1983