The Intracellular and Extracellular Fate of Oligodeoxyribonucleotides in Tissle Culture Systems

1 January 1989

journal article
research article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 8 (5) , 815-818
https://doi.org/10.1080/07328318908054220

Abstract

In this study, we analyzed the intracellular and extracellular stability of an oligdeoxyribonucleotide (oligo 293) which exhibits antiviral activity against Herpes Simplex Virus Type 1 (HSV-1) in tissue culture. The uptake and stability of oligo 293 varied when cell type or internucleoside linkage was changed.

Keywords

ANTIVIRAL
OLIGODEOXYRIBONUCLEOTIDES
FATE
EXTRACELLULAR
INTRACELLULAR
VIRUS
INTERNUCLEOSIDE
UPTAKE
TISSUE
SIMPLEX