Highly Efficient Chemical Kinetic Resolution of Bishomoallylic Alcohols: Synthesis of (R)-Sulcatol
- 24 August 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (19) , 3365-3367
- https://doi.org/10.1021/ol048608q
Abstract
A highly efficient chemical kinetic resolution of bishomoallylic alcohols was developed when the alcohols underwent In(OTf)3-catalyzed 3,5-oxonium-ene-type cyclization with steroidal aldehyde 2. Consistently high enantiomeric excess (up to >99%) was obtained.Keywords
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