Influence of Analgesics, Dromoran, Nisentil and Morphine, on Pain Thresholds in Man

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Abstract
Dromoran HC1 (3 mg.), Nisentil HC1 (30 mg.), and the control drug morphine sulfate (20 mg.) were tested in 12 normal human subjects by the tooth stimulation method and a new contact heat method called the warm wire method. Dromoran produced a significant rise in both pain thresholds which was equivalent to the morphine effect. Nisentil (probably because of inadequate dosage) failed to produce a significant rise in either threshold. The warm wire algesimeter merits further study as a method for measuring analgesia in clinical patients.