Oxygen Free Radical Injury Is Sufficient to Cause Some Alzheimer-Type Molecular Abnormalities in Human CNS Neuronal Cells

1 October 2000

journal article
Published by SAGE Publications in Journal of Alzheimer's Disease

Vol. 2 (3-4) , 261-281
https://doi.org/10.3233/jad-2000-23-406

Abstract

Cell loss and neuritic/cytoskeletal lesions represent two of the major categories of dementia-associated structural abnormalities in Alzheimer's disease (AD). Cell loss is ultimately mediated by apoptosis and mitochondrial DNA damage due to enhanced

Keywords

APOPTOSIS
STRUCTURAL
ULTIMATELY
DEMENTIA
SUFFICIENT
CNS
RADICAL
OXYGEN
LESIONS
MITOCHONDRIAL

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