Absolute Number of Circulating Sézary Cells

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Abstract
To the Editor.— Recent studies have demonstrated that Sézary cells are found in the circulation of normal persons1 and of patients with various inflammatory dermatoses2 and are not always found in the blood of patients with cutaneous T-cell lymphoproliferative disease.3 The demonstration of the cyclic nature of the presence of Sézary cells in the peripheral blood of patients with the Sézary syndrome has increased interest in the quantitation of Sézary cells.4 Expressing Sézary cells as a percentage of WBCs counted can give an erroneous impression. The Figure shows that the patient we observed had more than 15% Sézary cells in September and October 1979 and had cycles of cell values that peaked at more than 35% (Figure, left). When expressed as an absolute number of Sézary cells in relation to the total number of circulating WBCs, greatly different numbers were obtained (Figure, right). Cycles of Sézary

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