Amino alcohol effects on the ruthenium(II)-catalysed asymmetric transfer hydrogenation of ketones in propan-2-ol
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 2,p. 233-234
- https://doi.org/10.1039/cc9960000233
Abstract
A ruthenium(II) complex generated in situ from [{RuCl2(η6-C6Me6)}2], (1S,2S)-2-methylamino-1,2-diphenylethanol and KOH serves as an efficient catalyst for asymmetric transfer hydrogenation of acetophenone derivatives in propan-2-ol to give (S)-enriched alcohols in up to 92% ee and in > 90% yield.Keywords
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