Organization and expression of 5S rRNA genes in the parasitic nematode,Brugia malayi
- 1 January 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 17 (10) , 3773-3782
- https://doi.org/10.1093/nar/17.10.3773
Abstract
DNA sequence analysis of genes encoding 5S rRNA in the human parasitic nematode Brugia malayi (B. malayi) indicates a surprising degree of heterogeneity. This variation in coding sequence is not accompanied by corresponding heterogeneity in flanking regions which are highly conserved. Six out of eight potential 5S coding regions differed; of these sequence variants, two were abundant in the B. malayi genome. Direct RNA sequence analysis indicated that one of these abundant variants accounts for most if not all of expressed 5S RNA at two stages of development.This publication has 25 references indexed in Scilit:
- [57] Sequencing end-labeled DNA with base-specific chemical cleavagesPublished by Elsevier ,2004
- Tandemly repeated exons encode 81-base repeats in multiple, developmentally regulated Schistosoma mansoni transcripts.Molecular and Cellular Biology, 1988
- Isolation and genomic arrangement of active and inactive forms of mammalian 5 S RNA genes.Journal of Biological Chemistry, 1984
- Nucleotide sequences in Xenopus 5S DNA required for transcription terminationCell, 1981
- 5S Ribosomal RNA genes of the newt Notophthalmus viridescensNucleic Acids Research, 1981
- Repeated Genes in EukaryotesAnnual Review of Biochemistry, 1980
- Characterization of two xenopus somatic 5S DNAs and one minor oocyte-specific 5S DNACell, 1980
- Sequence and heterogeneity in the 5S RNA gene cluster of Drosophila melanogasterNucleic Acids Research, 1980
- On spacersCell, 1979
- DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences, 1977