Stereoselective α-alkylation of α,β-unsaturated esters utilizing conjugate addition of nitrogen nucleophiles (R2NLi)
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 1410-1411
- https://doi.org/10.1039/c39870001410
Abstract
Treatment of α,β-unsaturated esters (1) with lithium amides [LiNPri 2 and LiN(CH2Ph)SiMe3] followed by alkylation and elimination of the amino groups produced trisubstituted enoates (2) with high stereoselectivity.Keywords
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