Beta-Alanine, Like Glycine, Microinjected into the Rat Nucleus Tractus Solitarii Increases Blood Pressure
- 1 January 1990
- journal article
- Published by Taylor & Francis in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 12 (8) , 1351-1360
- https://doi.org/10.3109/10641969009073523
Abstract
Microinjections of β-alanine and glycine into the nucleus tractus solitarii (NTS) of the rat, led to an increase in blood pressure and heart rate. The responses to glycine but not to β-alanine could be blocked by strychnine. Both amino acids reduced the responses to aortic nerve stimulation. High K+ stimulation caused a calcium-dependent release of β-alanine from tissues in the area of the NTS. These results suggest that β-alanine and glycine may modulate the cardiovascular control within the NTS.Keywords
This publication has 16 references indexed in Scilit:
- Altered Amino Acid Levels in Brainstem Regions of Spontaneously Hypertensive RatsClinical and Experimental Hypertension. Part A: Theory and Practice, 1989
- Glycine, like glutamate, microinjected into the nucleus tractus solitarii of rat decreases arterial pressure and heart rateBrain Research, 1989
- Release by Electrical Stimulation of Endogenous Glutamate, γ‐Aminobutyric Acid, and Other Amino Acids from Slices of the Rat Medulla OblongataJournal of Neurochemistry, 1989
- Evidence for γ-aminobutyric acid receptor-mediated modulation of the aortic baroreceptor reflex in the nucleus tractus solitarii of the ratNeuroscience Letters, 1988
- A gamma‐aminobutyric‐acid‐mediated inhibition of neurones in the nucleus tractus solitarius of the cat.The Journal of Physiology, 1987
- Evidence for the presence of GABAergic and glycine-like systems responsible for cardiovascular control in the nucleus tractus solitarii of the ratNeuroscience Letters, 1987
- GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin releaseBrain Research, 1987
- Vasopressin-induced pressor responses in rats to bilateral electrolytic lesioning of the caudal portion of the nucleus tractus solitariiBrain Research, 1986
- evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathwayNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1982
- Superfusion of the hypothalamus with gamma-aminobutyric acidNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1973