The Effect of Single Doses of X Radiation on Mandibular Growth

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Abstract
The short-term effects of localized X radiation applied in single doses of 110, 550 and 1100 r on mandibular growth in the rat were examined. Intravital staining with the fluorochrome alizarin red S labelled bone mineralized immediately before irradiation. Analysis revealed a marked reduction in growth in every area examined in animals receiving 1100 r of X radiation. The greatest reductions were in the lingual alveolus (63%) and the condyle (36%). The lowest dose to produce any significant retardation of bone growth was 550 r where reductions of 12% in the inferior border and 9% in the condyle were recorded for male animals. At the 110 r level there was no measure-able reduction of bone growth.