SOME BIOLOGICAL ACTIONS OF IODO-l-THYRONINES
- 1 February 1960
- journal article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 20 (1) , 65-68
- https://doi.org/10.1677/joe.0.0200065
Abstract
SUMMARY Six iodo-l-thyronines, viz. 3:3′:5′-triiodo-, 3:5-diiodo-, 3:3′-diiodo-, 3′:5′-diiodo-, 3-monoiodo-, and 3′-monoiodo-l-thyronine, have been compared with 3:5:3′-triiodo-l-thyronine, in mice by an anoxia method and in rats for antigoitrogenic activities and effects on rate of oxygen consumption. The only compound with any significant activity was 3:5-diiodo-l-thyronine. In the goitre prevention assay it had 3% (on a weight basis) of the activity of 3:5:3′-triiodo-l-thyronine.Keywords
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