Two types of immature megakaryocytic series in the human fetal liver.

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Abstract
Megakaryocytes in the liver obtained from 185 human embryos and fetuses during the period from 28 days-22 wk of ovulation were investigated by light microscopy and EM. The early hepatic megakaryoblasts and the early heaptic promegakaryocytes at stage I observed in the intercellular spaces of the hepatocytes until 10 wk of ovulation (early stage of hepatic hemopoiesis) were larger than the late hepatic megakaryoblasts and the late hepatic promegakaryocytes at stage I observed after 10 wk of ovulation (late stage of hepatic hemopoiesis). The chromatin of the former 2 cells was finely dispersed; that of the latter 2 showed moderate central and peripheral clumping. Progenitor cells of the magakaryoblasts and the hemopoietic stem cells in the liver in the early stage of hepatic hemopoiesis morphologically differ from those in the liver in the late stage. Megakaryocytes in the liver until 10 wk of ovulation differ in maturation course from those after this ovulation stage.