Acute troglitazone action in isolated perfused rat liver

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Abstract
The thiazolidinedione compound, troglitazone, enhances insulin action and reduces plasma glucose concentrations when administered chronically to type 2 diabetic patients. To analyse to what extent thiazolidinediones interfere with liver function, we examined the acute actions of troglitazone (0.61 and 3.15 μM) on hepatic glucose and lactate fluxes, bile secretion, and portal pressure under basal, insulin‐ and/or glucagon‐stimulated conditions in isolated perfused rat livers. During BSA‐free perfusion, high dose troglitazone increased basal (P−1, P−1, P−1 min−1), PPPBritish Journal of Pharmacology (1999) 126, 372–378; doi:10.1038/sj.bjp.0702318