Effect of the Basidiomycete Poria cocos on Experimental Dermatitis and Other Inflammatory Conditions.
Open Access
- 1 January 1997
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 45 (3) , 492-494
- https://doi.org/10.1248/cpb.45.492
Abstract
The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID50 on acute TPA edema was 4.7×10-3 and 6.8×10-4 μmol/ear, respectively.Keywords
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