Bone Lesions in Cats With Anemia Induced by Feline Leukemia Virus2

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Abstract
Varying degrees of medullary osteosclerosis were in 12 of 13 cats with nonregenerative anemia induced by inoculation of feline leukemia virus (FeLV). In 7 cats with severe bone lesions, a trabecular network of cancellous bone extended from the primary spongiosum throughout the diaphysis and replaced the medullary marrow cavity. Despite the dramatic increase in medullary trabecular bone, histologic and ultrastructural examination of the bones indicated atrophy of osteoblasts and few osteoclasts, which implies general depression of bone growth and remodelling. C-type virus particles compatible with FeLV were associated with osteocytes, osteoblasts, and megakaryocytes, but not with other marrow cells.

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