Stereoselective Synthesis of the C13-C19 Fragment of the Cytotoxic Marine Products Calyculins; Part 21
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (04) , 285-286
- https://doi.org/10.1055/s-1991-20710
Abstract
The C13-C19 fragment of the cytotoxic marine products calyculins (1 or their antipodes) was stereoselectively prepared as the acyclic equivalent 2b [methyl (3R,4R,5S)-3,4-dibenzyloxy-5-methoxy-2,2-dimethyl-7-octenoate] from potassium (R)-2,3-O-isopropylideneglycerate (3) utilizing the stereoselective allylation of aldehyde 7 [(2S,3R)-2,3-dibenzyloxy-4,4-dimethyl-5-trityloxypentanal] in the presence of magnesium bromide.Keywords
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