In vitro assay of contractile activities of spastic canine basilar artery and its surrounding blood clot

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Abstract
A prolonged vasospasm was produced in the canine basilar artery by injection of fresh autogenous arterial blood into the chiasmatic cistern. Lyophilized normal and spastic canine basilar arteries and of lyophilized blood clot around the spastic artery, were homogenized, and their contractile activities were studied in vitro. The homogenates of the lyophilized spastic arteries usually induced a dose-dependent sustained contraction those of the lyophilized normal arteries often produced a dose-dependent transient contraction, and those of the lyophilized blood clot induced a dose-dependent transient or sustained contraction. The initial maximum contractions produced by the homogenates of the lyophilized normal and spastic arteries were significantly different suggesting the presence of a vasoactive agent in the spastic artery itself. Preliminary pharmacological analysis of the vasoactive agent was attempted using methysergide and phentolamine.

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