Prazosin kinetics in essential hypertension
- 30 June 1980
- journal article
- research article
- Published by Springer Nature in Clinical Pharmacology & Therapeutics
- Vol. 28 (1) , 6-11
- https://doi.org/10.1038/clpt.1980.123
Abstract
Prazosin kinetics were studied in 8 hypertensive patients (4 male and 4 female) with normal renal function. I.v. data showed a 3-phase distribution. A linear 3-compartment model with elimination from the central compartment was proposed to describe the drug kinetics. Prazosin disappeared from plasma with a terminal half-life t1/2 of .apprx. 3 h and had a central distribution volume of .apprx. 0.18/kg. Only a negligible fraction of the dose was unchanged in urine. The oral data showed that, of the 2 mg dose, .apprx. 1 mg was effectively absorbed. This fraction was absorbed in 2 h. Absorption kinetics were apparently linear with a t1/2 of .apprx. 30 min.This publication has 1 reference indexed in Scilit:
- New Method for Calculating the Intrinsic Absorption Rate of DrugsJournal of Pharmaceutical Sciences, 1968