Allergic contact dermatitis from fluocortolone, fluocortolone pivalate and fluocortolone caproate

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Abstract
Two patients with contact allergy to Ultralan® preparations are reported. Each Ultralan preparation contains two of three related fluocortolone derivatives. The first patient reacted to all three derivatives. The second patient reacted to fluocortolone and when retested 4 months later also to fluocortolone pivalate but not to fluocortolone caproate. The negative reaction to fluocortolone pivalate at the first examination was probably false negative due to a too low test concentration. In order to avoid false negative patch test reactions the fluorinated steroids should possibly be applied in concentrations higher than 1%. No cross sensitivity to the other steroids for topical use was found.

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