Effects of Nitroglycerin on H3-Catecholamine Metabolism

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Abstract
During the infusion of H3-epinephrine or H3-norepinephrine (0.15 [mu]g./Kg/min.) for 30 to 60 min. in 18 patients, nitroglycerin was administered to 6 cases with angina pectoris. The radioactivity of H3-epinephrine or H3-norepine-phrine in plasma and urine and its H3-acidic metabolites in urine were estimated in all cases. Similar measurements in the myocardium and plasma were carried out in 6 rabbits (3 non-treated and 3 pre-treated with nitroglycerin 3 min. before the infusion of H3-norepinephrine). From these studies, it is postulated that this drug acts as an accelerator of catecholamine inactivation. Further investigation will be needed.