The Extra Cytoplasmic Function Sigma Factor σ E Is Essential for Mycobacterium tuberculosis Virulence in Mice
Open Access
- 1 May 2004
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (5) , 3038-3041
- https://doi.org/10.1128/iai.72.5.3038-3041.2004
Abstract
The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.Keywords
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