Synthesis of monosulfates of cholic acid derivatives.

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Abstract
The 3-, 7- and 12-monosulfates of bile acids having an oxo or acetoxyl group on the steroid nucleus have been synthesized. Cholic acid derivatives appropriately protected were sulfated with chlorosulfonic acid and pyridine in the usual manner. The utilization of partial acetylation and hydrolysis together with chromium trioxide oxidation and sodium borohydride reduction provided the desired sulfates of cholic acid derivatives in satisfactory yields. The nuclear magnetic resonance spectral properties of the bile acid derivatives are briefly discussed.

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