A patient is described who showed a delayed recovery from suxamethonium on two occasions. Her esterase levels and liver function were estimated.The duration of action of suxamethonium is discussed and a test dose related to body weight is suggested.In the management of prolonged apnœa the need is stressed for continued narcosis together with an artificial respiration which will ensure not only oxygenation but also proper elimination of carbon dioxide.In order to avoid excessive narcosis which may simulate paralysis by a relaxant, it is suggested that the dose of thiopentone should be governed primarily by the weight of the patient. Five mg. per pound (0.45 kg.), used in conjunction with light premedication and nitrous oxide/oxygen anæsthesia, has been found satisfactory in most patients. In frail patients however the dose should be reduced to 2.5 mg. or even 1 mg. per pound (0.45 kg.).It is believed that if care is taken to avoid excessive narcosis, to employ always a test dose of suxamethonium and to perform artificial respiration correctly, antidotes such as ‘Cholase’ would not be necessary.