TISSUE TRANSPLANTATION AND THE RETICULOENDOTHELIAL SYSTEM I. Effect of Skin Grafts in Normal Animals

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Abstract
In the course of re-evaluating the effects of RES blockade upon homograft survival it was observed that: (a) Skin homografts produced a significant stimulation of the phagocytic properties of the RES of rats. This stimulation was first noted 7 days after grafting and had disappeared by 28 days. (b) The stimulation was of such a magnitude that amounts of thorotrast ordinarily capable of suppressing RES activity were no longer effective in grafted animals. Similarly, blockade produced prior to grafting was rapidly dispelled by the application of the homograft. (c) Heterografts likewise stimulated phagocytic activity of the RES. From this it is concluded that skin homografts provide such a marked stimulus to the RES that it is unlikely that blocking agents, when employed to the limit of safety, are effective in their presence. Consequently, the concept that blockade of the RES prolongs graft survival remains unproven.

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