Synthesis, Specific Intracellular Delivery and Biological Activity of Novel Stabilized (2′-5′)(A)nAnalogues

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Abstract
5’ and 2’ stabilized (2′-5′)(A)n analogues were synthesized by chemical modifications of enzymatically polymerized (2′-5′)(A)n oligomers. They exhibit an increased antiviral activity after micro-injection in HeLa cell cytoplasm in agreement with their augmented metabolic stability. Their specific in vitro delivery to mouse leukemia cells after encapsulation in targetted liposomes leads to a transient inhibition of protein synthesis and an antiviral activity.