DIFFERENCES BETWEEN THE RESULTS OF F. S. H.-MEASUREMENTS IN HYPOPHYSES OF RATS WITH EXTRACTION AND IMPLANTATION TECHNIQUES RESPECTIVELY

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Abstract
The F.S.H.-content of the hypophyses of intact testosterone-treated female rats is much higher than that of control animals. No such difference, however, is found if the glands are implanted intraperitoneally instead of being homogenized and extracted. In ovariectomized females a significant increase in the pituitary F.S.H.-content is noted under the influence of testosterone (hypophysis extracts), but a decreased F.S.H.-effect after implantation. Oestradiol markedly decreases the pituitary F.S.H.-content in spayed females (hypophyses homogenized and extracted). The difference with control glands appears much smaller, however, after intraperitoneal implantation. These discrepancies between the results of the two methods of administration are best explained by assuming that testosterone inhibits and oestrogen promotes the "release" of F.S.H. from the hypophyseal cells. Evidence is advanced in flavor of the existence of similar influences of sex hormones in the intact rat, on the pituitary gland in situ.

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