Synthesis of Amino Acid Derivatives of Neamine and 2-Deoxystreptamine to be used as Mutasynthons
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 10 (5) , 739-748
- https://doi.org/10.1080/07328309108543947
Abstract
6′-N derivatives of neamine with alanine, phenylalanine and lysine were synthesized either using an active esters method in one step under controlled conditions, or using a mixed anhydride method after blocking every functional group of neamine and leaving the 6′-amino group free to react. Similarly N,N′-diamino acid and monoamino acid derivatives of 2-deoxystreptamine were synthesized.Keywords
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