Dose Response Analysis of Pilocarpine-Induced Ocular Hypotension

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Abstract
Single dose loading with pilocarpine hydrochloride concentrations from 1% to 10% was performed in a series of open-angle glaucomatous patients. No significant differences in the ocular hypotensive response occurred at any dose level. On chronic administration, however, 4% pilocarpine produced a significant improvement over the 1% solution in both intraocular pressure and outflow facility. An increase in concentration to 8% produced no additional change in either factor.

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