Effects of experimental occlusion of the basilar artery by magnetic localization of iron filings on cerebral blood flow and metabolism and cerebrovascular responses to CO 2 in the dog

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Abstract
SUMMARYCerebral blood flow and metabolism were measured by the nitrous oxide technique and local cortical flow was measured by thermistor in anesthetized dogs before and after occlusion of the basilar artery by magnetically controlled iron filings. Responsivity of cerebral vessels to increased PaCO2 was measured before and after occlusion. Cerebral blood flow and metabolism and cortical flow decreased following occlusion. Cerebrovascular responsivity to increased PaCO2 was also reduced but not abolished. EEG changes did not correlate with changes in cerebral blood flow. It was concluded that: [1] interruption of afferent pathways in the brainstem causes reduction in cerebral oxygen and glucose consumption and secondary reduction in blood flow and [2] destructive brainstem lesions reduce response of cerebral vessels to CO2, denoting that action of CO2 on cerebral circulation cannot be explained by its local effect on cerebral vessels alone.

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