ANTICONVULSIVE ACTION OF VITAL DYES
- 1 December 1938
- journal article
- other
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 40 (6) , 1156-1177
- https://doi.org/10.1001/archneurpsyc.1938.02270120106007
Abstract
At different times during the past ten years the problem of cerebral anoxemia and its relation to certain convulsive phenomena has been studied in the laboratories of the department of neuropathology of the Harvard University Medical School.1A search was begun in 1935 for a stain which might act as an indicator of slight and early asphyxial changes in the nerve cells of the brain and spinal cord. It was observed that neutral red, injected intraperitoneally into mice, could be seen in the ventral horn cells of the spinal cord. This observation was definite, though rare. Asphyxia of the mice with nitrogen caused no increase in the amount of dye taken up by the ventral horn cells. In order to see the effect of the increased motor activity, we then planned to give the animals convulsant drugs. Accordingly, a study was begun by one of us (J. N.) inKeywords
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