Steel factor and c‐Kit receptor: From mutants to a growth factor system
- 5 February 1993
- Vol. 15 (2) , 77-83
- https://doi.org/10.1002/bies.950150202
Abstract
Mutations within the Steel and Dominant Spotting loci of mice have led to the recent identification of a growth factor/receptor system required for the normal development of germ cells, pigment cells and hematopoietic cells. Interactions between the products of these genes, Steel factor and c‐Kit respectively, have now been demonstrated to influence various developmental processes, including survival, proliferation, and/or differentiation of cells in a tissue specific manner. In addition, our current understanding of the molecular basis of various Steel and Dominant Spotting alleles coupled with the emerging information on the expression pattern of steel factor and c‐kit transcripts during development, is now beginning to explain the pleiotropic affects of these mutations.Keywords
This publication has 45 references indexed in Scilit:
- Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors.Genes & Development, 1991
- Expression of c-kit encoded at the W locus of mice in developing embryonic germ cells and presumptive melanoblastsDevelopmental Biology, 1991
- The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells.The Journal of Experimental Medicine, 1991
- Steel locus defines new multipotent growth factorCell, 1990
- The kit ligand: A cell surface molecule altered in steel mutant fibroblastsCell, 1990
- Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kitNature, 1990
- Identification of a ligand for the c-kit proto-oncogeneCell, 1990
- Extracellular matrix from normal but not Steel mutant mice enhances melanogenesis in cultured mouse neural crest cellsDevelopmental Biology, 1990
- Mouse mutants provide new insights into the role of extracellular matrix in cell migration and differentiationTrends in Genetics, 1989
- A presumed deletion covering theWandPhloci of the mouseGenetics Research, 1984