Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogs
- 1 January 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (1) , 63-69
- https://doi.org/10.1021/jm00187a015
Abstract
A series of melatonin analogus was synthesized and examined for ovulation-blocking activity in rats. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the .alpha.-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.This publication has 3 references indexed in Scilit:
- Synthesis of ring‐fluorinated serotonins and melatoninsJournal of Heterocyclic Chemistry, 1976
- RELATIVE POTENCIES OF INDOLIC + RELATED COMPOUNDS IN BODY-LIGHTENING REACTION OF LARVAL XENOPUS1964
- The Fate of Melatonin in AnimalsJournal of Biological Chemistry, 1961