ON THE INFLUENCE OF 3-KETO-STEROIDS ON THE PHOSPHATASE CONTENT OF ATYPICALLY PROLIFERATING UTERINE EPITHELIUM IN THE GUINEA PIG

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Abstract
Alkaline and acid phosphatases were detd. separately in the uterine mucosa (and submucosa) and the myometrium of castrated female guinea pigs to which estrogens were given for a long time. The method of King and Armstrong was used. A considerable increase of alkaline phosphatase took place in the mucosa, or submucosa, especially in the first 2 months. When expts. were prolonged for several months, alkaline phosphatase tended to decrease again. When progesterone was admd. simultaneously with extrogen, the alkaline phosphatase increase in the mucosa, or submucosa, was counteracted so as to attain, under certain quantitative conditions, the same level as in non-treated animals. A similar though less pronounced anti-phosphatase action was observed with androgens. There was only a slight increase of alkaline phosphatase in the myometrium when greatly hyper-trophied under the influence of estrogen. No increase of acid phosphatase took place in any part of the uterus under the influence of estrogen. There was no increase of alkaline or acid phosphatase in estrogen-induced uterine or extrauterine abdominal fibroids.

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