Failure of Thymopoietin, Ubiquitin and Synthetic Serum Thymic Factor to Restore Immunocompetence in T-Cell Deficient Mice
- 1 November 1978
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 159 (2) , 195-200
- https://doi.org/10.3181/00379727-159-40313
Abstract
Thymopoietin, ubiquitin and serum thymic factor, all of which induce T [thymus-derived] cell markers on lymphocytes, were evaluated for their capacity to induce thymus-dependent activities in vivo. Multiple treatments over a period of weeks failed to restore resistance to line Ib leukemia or responses to T cell mitogens in T cell-deficient C58 mice. These substances apparently are ineffective in inducing thymus-dependent immunocompetence that is meaningful in the intact animal.This publication has 1 reference indexed in Scilit:
- Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.Proceedings of the National Academy of Sciences, 1977