BENEFICIAL-EFFECTS OF BUCINDOLOL IN A CANINE MODEL OF PENTOBARBITAL-INDUCED HEART-FAILURE

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 250  (1) , 65-72
Abstract
Heart failure was induced in barbital-anesthetized dogs by administering high doses of pentobarbital. This procedure depresses cardiac function as indicated by a reduction in right ventricular contractile force (RVCF), left ventricular dp/dt [rate of pressure change] and aortic blood flow. Bucindolol (0.1 and 0.1 mg/kg per h) stimulated the depressed indications of cardiac function. Both RVCF and aortic blood flow returned to prefailure levels, left ventricular dp/dt increased 43% but heart rate was elevated only slightly (14%). Total peripheral resistance was lowered 36% by bucindolol. The combination of myocardial stimulation and vasodilatation which contributed to the positive results in this acute model of pump failure suggests a possible role for bucindolol in the clinical management of congestive heart failure. Bucindolol, in contrast to propranolol, could be used in a sub-group of hypertensive patients with depressed cardiac function.