Endosulfan Toxicity and Dietary Protein

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Abstract
Male albino rats were fed for 28 days from weaning on a diet containing 0% (group 1), 3m5% (group 2), 9% (group 3), 26% (group 4), or 81% (group 5) protein as casein. At the end of the dieting period, the acute oral median lethal dose ± standard error of the mean (LD5o ± SE) of endosulfan, in milligrams per kilogram of body weight, was 5.1 ± 1.4 in group 1, 24 ± 10 in group 2, 57 ± 4 in group 3, 102 ± 16 in group 4, and 98 ± 7 in group 5. The syndrome of intoxication to endosulfan at the range of the acute oral LD50 was essentially the same in animals of ali five groups and consisted of stimulation of the central nervous system, an irritant gas-iroenteritis, and congestion of the brain and liver. Augmentation of susceptibility of protein-deficient rats to toxic effects of pesticides varied considerably from agent to agent.