Distribution and Further Studies on the Activity of Prostaglandin E in Chronic Granulomatous Inflammation
- 1 January 1979
- book chapter
- Published by Springer Nature
- No. 6,p. 121-132
- https://doi.org/10.1007/978-3-0348-7232-4_14
Abstract
Pre-formed granulomata, induced by cannulated, carrageenin-soaked, subdermal sponge implants, were used to further analyse the effects of exogenous PGE and the involvement of endogenous PGE in this model of chronic inflammatory tissue changes in rats. Experiments with 14C-PGE2 indicated that administration of PGE into the sponge creates a kinetic situation likely to imitate, but superimposed upon, the continuous discharge of endogenous PGE in the granuloma. The granuloma-reducing, anti-flammatory effect of PGE can be mimicked by dibutyryl cyclic-AMP, phosphodiesterase inhibitors and indomethacin. Most probably these compounds, in common with PGE, exert their anti-granuloma action through elevation of intracellular cyclic-AMP (in macrophages and/or fibroblasts). The anti-granuloma action is not necessarily associated with a reduction in the endogenous PGE-level and vice versa. The involvement of endogenous PGE in the tissue events of granulomatous inflammation is conjectural as yet.Keywords
This publication has 16 references indexed in Scilit:
- Cannulated teflon chamber implant in the rat: A new model for continuous studies on granulomatous inflammationJournal of Pharmacological Methods, 1979
- Distinction between prostaglandin E2 and prostacyclin as inhibitors of granulomatous inflammationJournal of Pharmacy and Pharmacology, 1979
- Cannulated sponge implants in rats for the study of time-dependent pharmacological influences on inflammatory granulomataJournal of Pharmacological Methods, 1979
- Prostaglandin E1 reversibly induces morphological changes in macrophages and inhibits phagocytosisExperimental Cell Research, 1979
- Combination of theophylline and prostaglandin E1 as inhibitors of the adjuvant-induced arthritis syndrome of rats.Annals of the Rheumatic Diseases, 1978
- Prostaglandin and thromboxane synthesis in a pure macrophage population and the inhibition, by E‐type prostaglandins, of chemiluminescenceFEBS Letters, 1978
- Bioassay by cascade superfusion using a highly sensitive laminar flow techniqueJournal of Pharmacy and Pharmacology, 1977
- Influence of prostaglandins on connective tissue cell growth and functionNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1977
- A laminar flow superfusion technique with much increased sensitivity for the detection of smooth muscle-stimulating substancesEuropean Journal of Pharmacology, 1976
- Stimulation of human platelet adenylate cyclase by prostaglandin D2Thrombosis Research, 1974