Echocardiographic analysis of systolic and diastolic left ventricular wall motion during transient myocardial ischemia

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Abstract
Left ventricular (LV) wall motion (anterior and posterior) and simultaneous LV pressure were recorded during 30-second left anterior descending (LAD) or circumflex (CX) coronary artery occlusions in open-chest dogs to provide an echocardiographic model of the evolution of wall motion changes during myocardial ischemia. Prominent diastolic echocardiographic motion changes of progressive decrease in LV wall rapid-filling velocities (RFS), slow-filling velocities (SFS), and increased end-diastolic diameter were accompanied by a marked increase in initial and end-diastolic pressures (150% and 70%, respectively; all p < 0.05). Early (within ten seconds) and progressive decrease in rate (SES), amplitude (E), and duration (TTR) of systolic motion were noted with an increased systolic diameter (p < 0.05). Ischemic regions developed a characteristic pattern with early relaxation followed by a diastolic inward motion (DIM). These observations confirm and extend other investigators' findings on the motion of the ischemic myocardium and may be applicable to responses to transient myocardial ischemia noted in humans.