Serological Analysis of Components in Hemopoietic Tissue.

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Abstract
In a previous paper it was described how serious damage to the hemopoiesis could be produced in rabbits by injns. of horse antiserum to rabbit bone-marrow. As a basis for the present study it was presumed that the hemopoietic tissue contains several antigenic components, some of which may be connected with function or structure of the blood-forming system. Using a special serol. method, 4 non-humoral antigenic components were demonstrated in the bone-marrow. None of these components was strictly specific to this organ. They were found also in liver, spleen, lung and adrenal although none of these organs contained the complete set of these antigens. Of the organs examined the spleen came closest to the bone-marrow in respect of antigenic structure. It is suggested that the biological effect of the antibone-marrow hyperimmune serum is connected with a reaction between serum antibodies and the antigens described.