TWO-GUEST INCLUSION COMPLEX OF γ-CYCLODEXTRIN WITH CHLORPROMAZINE
- 5 February 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 12 (2) , 233-236
- https://doi.org/10.1246/cl.1983.233
Abstract
The interaction of chlorpromazine with γ-cyclodextrin in an aqueous solution was studied by circular dichroism and 1H-NMR. γ-Cyclodextrin was found to form a 1:2 inclusion complex with chlorpromazine at a concentration higher than ca. 1×10−4mol·l−1. The two chlorpromazine molecules including in γ-cyclodextrin may have S-helicity.Keywords
This publication has 1 reference indexed in Scilit:
- Inclusion complexes of .BETA.-cyclodextrin with tranquilizing drugs phenothiazines in aqueous solution.CHEMICAL & PHARMACEUTICAL BULLETIN, 1975