BCL10 deletions in haematological malignancies: a cloning artefact?
- 1 December 2000
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 111 (4) , 1106-1108
- https://doi.org/10.1046/j.1365-2141.2000.02447.x
Abstract
Mutations within the BCL10 gene, a gene involved in apoptosis, have recently been found to occur in a variety of cancers and it was suggested that BCL10 was involved in the pathogenesis of human malignancies. Our investigations of the involvement of this gene in various malignancies, however, do not uphold this suggestion. We would like to propose that, in fact, the original results were obtained as a result of a rare cloning artefact.Keywords
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