An experimental study of the mechanism of andrographis paniculata nees (APN) in alleviating the Ca2+-overloading in the process of myocardial ischemie reperfusion

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Abstract
The aim of this experiment is to study the mechanism of APN in alleviating the Ca2+-overloading in dog model during the process of ischemic reperfusion. In comparison with the sustained ischemic group, the parameters in the ischemic reperfusion group demonstrated: Ca2+ of ischemie region of myocardial cell increased (P+ increased remarkablyP2+-ATPase dropped remarkably (PP2+ in the relevant area reduced (P+ decreased significantly (P2+-ATPase and Na+-K+ ATPase increased remarkably (PP2+ and Na+-overloading by decreasing the harmful effect of oxygen free radicals.