Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.
Open Access
- 1 October 1982
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 2 (10) , 1295-1298
- https://doi.org/10.1128/mcb.2.10.1295
Abstract
Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.This publication has 18 references indexed in Scilit:
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