Effects of Ethanol and a Fat-Free Diet on Hepatic Mitochondrial Fragility and Fatty Acid Composition

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Abstract
The effect of EFA deficiency and chronic ethanol ingestion on liver mitochondrial fragility and fatty acid composition was studied using young growing male rats. The results indicated that EFA deficiency (fat-free diet) partially protected the mitochondria from developing the increased fragility caused by ethanol ingestion. The mitochondrial fragility induced by chronic ethanol feeding was not related to changes in the proportions of arachidonic acid or other mitochondrial fatty acids. Additionally, it was found that chronic ethanol feeding partially prevented the changes in the mitochondrial fatty acid composition induced by EFA deficiency.

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