Trimethylchlorosilane: a novel activating reagent in nucleotide synthesis via the phosphoramidite route
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 9,p. 877-878
- https://doi.org/10.1039/a701924f
Abstract
Trimethylchlorosilane (TMSCl) is a remarkably efficient activator in the reaction of phosphorus(III) amides with nucleosides to give phosphorus(III) esters in excellent yield.Keywords
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