Vereinfachte Peptidsynthese mit schutzgruppenfreien Aminosäure-Hydrochloriden nach dem Prinzip der Vierkomponenten-Kondensation
- 1 January 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (09) , 837-838
- https://doi.org/10.1055/s-1992-26240
Abstract
Simplified Synthesis of Peptides with Non-protected Amino acid hydrochlorides via Four-Component Condensation Synthesis of sulfur containing peptide analogues, 3-(ω-aminoalkanoyl)-2, 2-dimethyl-1,3-thiazolidine-4-carboxamides 2, via Ugi four-component condensation (4CC) starting from 2,5-dihydro-1,3-thiazoles 1, isocyanides and non-protected amino acid hydrochlorides is described. Involvement of N-phthaloyl amino acids in a typical 4CC and following dephthaloylation of the resulting compounds 2,2-dimethyl-3-(ω-phthalimidoalkanoyl)-1, 3-thiazolidine-4-carboxamides 3, affords peptides 2 in lower overall yields than by the one-step way.Keywords
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